The new video includes a boat ride down the Mississippi River while a horde of Chimera attack from nearby land and subsequently hop on board.
Playstation 3 will be sold Sept. 6, 2011 at U.S. retail.
The title will include a full campaign mode and new two-player online and split-screen co-op functionality.
The final game will include new weapon upgrades and new enemies.
The competitive multiplayer mode will include human vs. Chimera battles in deathmatch and objective-based modes. Users can spend earned points to customize loadouts, including new personal and support abilities.
Support abilities include the Bubble Shield, Ammo Beacon to give ammo to teammates, and Radar Beacon to enhance the team’s radar.
Tactical abilities include Doppelganger to project an image distraction and Dash for a speed burst to evade enemy attacks.
A multiplayer beta is planned for later this year.
The prior installment, Resistance 2, was released in Nov. 2008.
Resistance: Fall of Man was a launch title offering in Nov. 2006.